Synthetic Route of 1826-11-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 1826-11-5, Name is 2-Phenylthiazole. In a document type is Article, introducing its new discovery.
Trimethylsulfoxonium ylide reacts with 4-dimethylamino-1-thia-3-azabutadienes (N2-thioacylamidines) affording thiazol-2-ines, through a regioselective reaction corresponding to a nucleophilic attack on the amidine group.Thiazoles are obtained by reaction of phenyl isocyanate with 4-amino-thiazol-2-ines.Addition of methylenetriphenylphosphorane to N2-acyl or N2-thioacylamidines occurs by a similar pathway, but the intermediate betaine is stable at room temperature.Hydrolysis affords a dimethylaminovinylphosphonium salt.In boiling toluene or tetrahydrofuran, dimethylamine elimination occurs, leading to N-acyl or N-thioacyliminoethylidenetriphenylphosphoranes.An X-ray structural determination is achieved.Key Words: N-thioacylformamidine / 1-thia-3-azabutadiene / thiazol-2-ine / thiazole / vinylphosphonium / methylenetriphenylphosphorane
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Reference：
Thiazole | C3H3896NS – PubChem,
Thiazole | chemical compound | Britannica