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Imidazo<1,2-b>pyridazines. X. Syntheses and Central Nervous System Activities of Some 3-(Acetamido, benzamido, substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6-(halogeno, alkylthio, alkoxy, phenylthio, phenoxy, benzylthio or benzyloxy)imidazo<1,2-b>pyridaz
Syntheses of some 3-(acetamido, benzamido, substituted benzamido or dimethylamino)methyl-2-(phenyl or substituted phenyl)-6-(halogeno, alkylthio, alkoxy, phenylthio, phenoxy, benzylthio or benzyloxy)imidazo<1,2-b>pyridazines from the 3-unsubstituted analogues are described.The IC50 values (or percentage displacements) are reported and discussed for the displacement of <3H>diazepam from rat brain membrane by each of these compounds.The 3-benzamidomethyl compounds were generally the most active; of these, 3-benzamidomethyl-2-(3′,4′-methylenedioxyphenyl)-6-methylthioimidazo<1,2-b>pyridazine showed oustanding activity with IC50 2 nM.
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Reference：
Thiazole | C3H8464NS – PubChem,
Thiazole | chemical compound | Britannica