In an article, published in an article, once mentioned the application of 566169-93-5, Name is 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol,molecular formula is C14H12N2OS, is a conventional compound. this article was the specific content is as follows.category: thiazole
2-Phenylbenzothiazole conjugated with cyclopentadienyl tricarbonyl [CpM(CO)3] (M = Re, 99mTc) complexes as potential imaging probes for beta-amyloid plaques
Technetium-99m-labeled cyclopentadienyl tricarbonyl complexes conjugated with the 2-phenylbenzothiazole binding motif were synthesized. The rhenium surrogates 20, 21, 22 and 23 were demonstrated to have moderate to high affinities for Abeta1-42 aggregates with Ki values of 142, 76, 64 and 24 nM, respectively. During the fluorescence staining of brain sections of transgenic mice and patients with Alzheimer’s disease, these rhenium complexes demonstrated perfect and intense labeling of Abeta plaques. Moreover, in in vitro autoradiography, 99mTc-labeled complexes clearly detected beta-amyloid plaques on sections of brain tissue from transgenic mice, which confirmed the sufficient affinity of these tracers for Abeta plaques. However, these compounds did not show desirable properties in vivo, especially showing poor brain uptake (below 0.5% ID g-1), which will hinder the further development of these tracers as brain imaging agents. Nonetheless, it is encouraging that these 99mTc-labeled complexes designed by a conjugate approach displayed sufficient affinities for Abeta plaques. This journal is
Do you like my blog? If you like, you can also browse other articles about this kind. category: thiazole. Thanks for taking the time to read the blog about 566169-93-5
Reference：
Thiazole | C3H448NS – PubChem,
Thiazole | chemical compound | Britannica