Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1603-91-4, Name is 4-Methylthiazol-2-amine, SDS of cas: 1603-91-4.
Thienylimidazo[2,1-b]thiazoles as inhibitors of mitochondrial NADH dehydrogenase
The synthesis of 6-substituted 5-(thienylvinyl)imidazo[2,1-b]thiazoles and 6-thienylimidazo[2,1-b]thiazoles is reported. These compounds were tested as specific inhibitors of the NADF-ubiquinone (UBQ) reductase activity of NADH dehydrogenase in mitochondrial membranes. The 6-thienylimidazo[2,1-b]thiazoles were more potent in mammalian than in nematode mitochondria and had an average titer of 0.11 mM for 2-methyl-6-(2-thienyl)imidazo[2,1-b] thiazole (10). This compound is noncompetitive with the ubiquinone substrate and interacts with a site which is mutually exclusive with that of rotenone but nonexclusive with that of piericidin and several other inhibitors of NADH dehydrogenase. In the series of 5-(thienylvinyl) imidazothiazoles, the hydrobromide of (E)-6-chloro-5-(2-thienylvinyl)imidazo[2,1-b]thiazole(E-5-HBr) was found to be more potent as an inhibitor of the NADH:UBQ activity (IC50 = 15-17 muM) than the 6-thienylimidazoles such as 10. The inhibitory action of E-5·HBr and its analogs is different from that of compound 10 as indicated by the mutual exclusivity with other inhibitors and the relative inhibition of the activity with various electron acceptors.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 1603-91-4. In my other articles, you can also check out more blogs about 1603-91-4
Reference：
Thiazole | C3H9608NS – PubChem,
Thiazole | chemical compound | Britannica