Synthetic Route of 884-22-0, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.884-22-0, Name is Methyl 6-methoxybenzo[d]thiazole-2-carboxylate, molecular formula is C10H9NO3S. In a patent, introducing its new discovery.
Selective NR1/2B N-methyl-D-aspartate receptor antagonists among indole-2-carboxamides and benzimidazole-2-carboxamides
(4-Benzylpiperidine-1-yl)-(6-hydroxy-1H-indole-2-yl)-methanone (6a) derived from (E)-1 -(4-benzylpiperidin-1-yl)-3-(4-hydroxy-phenyl)-propenone (5) was identified as a potent NR2B subunit-selective antagonist of the NMDA receptor. To establish the structure-activity relationship (SAR) and to attempt the improvement of the ADME properties of the lead, a series of compounds were prepared and tested. Several derivatives showed low nanomolar activity both in the binding and in the functional assay. In a formalin-induced hyperalgesia model in mice, 6a and (4-benzylpiperidine-1-yl)-[5(6)-hydroxy-1H-benzimidazol-2- yl]-methanone (60a) were as active as besonprodil (2) after oral administration. A CoMS1A model was developed based on binding data of a series of indole- and benzimidazole-2-carboxamides.
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Reference：
Thiazole | C3H8511NS – PubChem,
Thiazole | chemical compound | Britannica