The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.32955-21-8, Name is Ethyl 2-aminothiazole-5-carboxylate, molecular formula is C6H8N2O2S. In a Article，once mentioned of 32955-21-8, SDS of cas: 32955-21-8
136. Triple-Helix Formation by Pyrimidine Oligonucleotides Containing Nonnatural Nucleosides with Extended Aromatic Nucleobases: Intercalation from the Major Groove as a Method for Recognizing C·G and T·a Base Pairs
The sequence-specific recognition of double-helical DNA by oligonucleotide-directed triple helix formation is limited primarily to purine tracts. To identify potential lead compounds which are able to extend the sequence repertoire of triple helical complexes, we designed two carbocyclic nucleosides with nucleobases attached via amide bonds. N 5-[(1R,2S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-2-methoxycyclopentyl]-2- {[1H-pyrrol-2-yl)carbonyl]-amino}thiazole-5-carboxamide (L1) and 2-benzamido-N 5-[(1R,2S,3R,4R)-3-hydroxy-4-(hydroxymethyl)-2-methoxycyclopentyl] thiazole-5-carboxamide (L2) were synthesized and incorporated into pyrimidine oligonucleotides. The 2-(trimethylsilyl)ethoxymethyl (SEM) protecting group for the 1H-pyrrole NH was found to be compatible with DNA solid-phase synthesis of pyrimidine oligonucleotides. By quantitative DNase I footprinting analysis, both nonnatural nucleosides L1 and L2 showed preferential binding of pyrimidine over purine bases: L1/2 · (C-G) ? L1/2 · (T · A) > L1/2?(G · C) ? L1/2 · (A · T). Comparison with the previously reported nonnatural nucleosides with extended aromatic nucleobases 1-(2-deoxy-beta-D-ribofuranosyl)-4-(3-benzamidophenyl)-imidazole (D3) and N4-[6-(benzamido)pyridin-2-y1]-2?-deoxycytidine (bzM) suggests that the observed binding selectivity C · G ? T · A > G · C ?A · T for the nucleoside analogs L1, L2, D3, and bzM is derived from sequencespecific intercalation with preferential stacking of their nucleobases over pyrimidine · purine Watson-Crick base pairs.
The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 32955-21-8 is helpful to your research., SDS of cas: 32955-21-8
Reference：
Thiazole | C3H7967NS – PubChem,
Thiazole | chemical compound | Britannica