Reference of 848501-90-6. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 848501-90-6, Name is 2-Bromo-4-cyanothiazole. In a document type is Article, introducing its new discovery.
Holo structure and steady state kinetics of the thiazolinyl imine reductases for siderophore biosynthesis
Thiazolinyl imine reductases catalyze the NADPH-dependent reduction of a thiazoline to a thiazolidine, a required step in the formation of the siderophores yersiniabactin (Yersinia spp.) and pyochelin (Pseudomonas aeruginosa). These stand-alone nonribosomal peptide tailoring domains are structural homologues of sugar oxidoreductases. Two closed structures of the thiazolinyl imine reductase from Yersinia enterocolitica (Irp3) are presented here: an NADP+-bound structure to 1.45 A resolution and a holo structure to 1.28 A resolution with NADP+ and a substrate analogue bound. Michaelis-Menten kinetics were measured using the same substrate analogue and the homologue from P. aeruginosa, PchG. The data presented here support the hypothesis that tyrosine 128 is the likely general acid residue for catalysis and also highlight the phosphopantetheine tunnel for tethering of the substrate to the nonribosomal peptide synthetase module during assembly line biosynthesis of the siderophore.
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Reference：
Thiazole | C3H2430NS – PubChem,
Thiazole | chemical compound | Britannica