A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 859522-19-3, Name is Ethyl 2-((2-aminothiazol-5-yl)thio)acetate, molecular formula is C7H10N2O2S2. In a Article，once mentioned of 859522-19-3, Recommanded Product: Ethyl 2-((2-aminothiazol-5-yl)thio)acetate
Systemically acting glucokinase activators (GKA) have been demonstrated in clinical trials to effectively lower blood glucose in patients with type II diabetes. However, mechanism-based hypoglycemia is a major adverse effect that limits the therapeutic potential of these agents. We hypothesized that the predominant mechanism leading to hypoglycemia is GKA-induced excessive insulin secretion from pancreatic beta-cells at (sub-)euglycemic levels. We further hypothesized that restricting GK activation to hepatocytes would maintain glucose-lowering efficacy while significantly reducing hypoglycemic risk. Here we report the discovery of a novel series of carboxylic acid substituted GKAs based on pyridine-2-carboxamide. These GKAs exhibit preferential distribution to the liver versus the pancreas in mice. SAR studies led to the identification of a potent and orally active hepatoselective GKA, compound 6. GKA 6 demonstrated robust glucose lowering efficacy in high fat diet-fed mice at doses ?10 mpk, with ?70-fold liver:pancreas distribution, minimal effects on plasma insulin levels, and significantly reduced risk of hypoglycemia.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Recommanded Product: Ethyl 2-((2-aminothiazol-5-yl)thio)acetate, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 859522-19-3, in my other articles.
Reference：
Thiazole | C3H7724NS – PubChem,
Thiazole | chemical compound | Britannica