564443-27-2, Name is 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde, molecular formula is C7H3F3N2OS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 564443-27-2, Quality Control of: 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde
A new class of imidazo[2,1-b]thiazole chalcone derivatives were synthesized and evaluated for their anticancer activity. These chalcone derivatives show promising activity, with logGI50 values ranging from -7.51 to -4.00. The detailed biological aspects of these derivatives toward the MCF-7 cell line were studied. Interestingly, these chalcone derivatives induced G 0/G1-phase cell-cycle arrest, down-regulation of G 1-phase cell-cycle regulatory proteins such as cyclin D1 and cyclin E1, and up-regulation of CDK4. Moreover, these compounds elicit the characteristic features of apoptosis such as enhancement in the levels of p53, p21, and p27, suppression of NF-kappaB, and up-regulation of caspase-9. One of these chalcone derivatives, 3d, is potentially well suited for detailed biological studies, either alone or in combination with existing therapies. Breaking the cycle: We undertook an extensive examination of the ability of a series of new chalcone derivatives to regulate the cell cycle and to induce apoptosis in various cancer cell lines. Compound 3d is a particularly suitable candidate for further detailed biological investigations, especially in the treatment of breast cancer.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 6-(Trifluoromethyl)imidazo[2,1-b]thiazole-5-carbaldehyde. In my other articles, you can also check out more blogs about 564443-27-2
Reference：
Thiazole | C3H6754NS – PubChem,
Thiazole | chemical compound | Britannica