885465-97-4, Name is 3-Thiazol-2-yl-benzaldehyde, molecular formula is C10H7NOS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 885465-97-4, Product Details of 885465-97-4
We have identified several series of small molecule inhibitors of TrkA with unique binding modes. The starting leads were chosen to maximize the structural and binding mode diversity derived from a high throughput screen of our internal compound collection. These leads were optimized for potency and selectivity employing a structure based drug design approach adhering to the principles of ligand efficiency to maximize binding affinity without overly relying on lipophilic interactions. This endeavor resulted in the identification of several small molecule pan-Trk inhibitor series that exhibit high selectivity for TrkA/B/C versus a diverse panel of kinases. We have also demonstrated efficacy in both inflammatory and neuropathic pain models upon oral dosing. Herein we describe the identification process, hit-to-lead progression, and binding profiles of these selective pan-Trk kinase inhibitors.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 885465-97-4. In my other articles, you can also check out more blogs about 885465-97-4
Reference：
Thiazole | C3H4560NS – PubChem,
Thiazole | chemical compound | Britannica