211940-25-9, Name is 2-Ethynyl-4-methylthiazole, molecular formula is C6H5NS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 211940-25-9, SDS of cas: 211940-25-9
A novel series of 4-thiazolylimidazoles was synthesized as transforming growth factor-beta (TGF-beta) type I receptor (also known as activin receptor-like kinase 5 or ALK5) inhibitors. These compounds were evaluated for their ALK5 inhibitory activity in an enzyme assay and their TGF-beta-induced Smad2/3 phosphorylation inhibitory activity in a cell-based assay. N-{[5-(1,3-benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-2-yl] methyl}butanamide 20, a potent and selective ALK5 inhibitor, exhibited good enzyme inhibitory activity (IC50 = 8.2 nM) as well as inhibitory activity against TGF-beta-induced Smad2/3 phosphorylation at a cellular level (IC50 = 32 nM).
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.SDS of cas: 211940-25-9. In my other articles, you can also check out more blogs about 211940-25-9
Reference：
Thiazole | C3H3278NS – PubChem,
Thiazole | chemical compound | Britannica