Synthetic Route of 69812-29-9. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 69812-29-9, Name is 2-Acetamido-4-methylthiazole-5-sulfonyl chloride. In a document type is Article, introducing its new discovery.
A series of novel 12N-substituted matrinane derivatives were synthesized and evaluated for their activities against coxsackievirus type B3 (CVB3) taking compound 1 as the lead. SAR analysis indicated that the introduction of a suitable heteroaromatic ring on the 12N-atom might be beneficial for the activity. Among them, compound 8a exhibited the highest potency against all CVB serotypes as well as CVA16 with IC50values ranging from 2.02 muM to 7.41 muM, indicating a broad-spectrum anti-coxsackieviruse effect. Furthermore, compound 8a demonstrated a good safety profile in vivo. Thus, we consider 12N-substituted matrinanes to be a promising family of anti-coxsackievirus agents, and compound 8a to be a promising drug candidate in the treatment of various diseases related to coxsackievirus infection.
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Reference：
Thiazole | C3H1809NS – PubChem,
Thiazole | chemical compound | Britannica