The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.198904-53-9, Name is 4-(Thiazol-2-yl)benzaldehyde, molecular formula is C10H7NOS. In a Article，once mentioned of 198904-53-9, Application In Synthesis of 4-(Thiazol-2-yl)benzaldehyde
Fragment-based drug discovery is intimately linked to fragment extension approaches that can be accelerated using software for de novo design. Although computers allow for the facile generation of millions of suggestions, synthetic feasibility is however often neglected. In this study we computationally extended, chemically synthesized, and experimentally assayed new ligands for the beta2-adrenergic receptor (beta2AR) by growing fragment-sized ligands. In order to address the synthetic tractability issue, our in silico workflow aims at derivatized products based on robust organic reactions. The study started from the predicted binding modes of five fragments. We suggested a total of eight diverse extensions that were easily synthesized, and further assays showed that four products had an improved affinity (up to 40-fold) compared to their respective initial fragment. The described workflow, which we call “growing via merging” and for which the key tools are available online, can improve early fragment-based drug discovery projects, making it a useful creative tool for medicinal chemists during structure-activity relationship (SAR) studies.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of 4-(Thiazol-2-yl)benzaldehyde, you can also check out more blogs about198904-53-9
Reference：
Thiazole | C3H4877NS – PubChem,
Thiazole | chemical compound | Britannica