Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 5331-91-9, C7H4ClNS2. A document type is Article, introducing its new discovery., Recommanded Product: 5-Chlorobenzo[d]thiazole-2(3H)-thione
The direct acylation of sulfonamides by esters represents an attractive strategy in organic chemistry, being an interesting alternative to classical approaches to N-acylsulfonamides. Here is described a simple and effective method to obtain N-acylsulfonamides of pharmaceutical interest, in a reaction promoted by titanium(IV) chloride. This strategy was successfully applied to the synthesis of a peroxisome proliferator-activated receptor antagonist with a benzenesulfonimide moiety, ensuring an excellent yield of product. The reaction was further studied to explore the behavior of different -bromoesters and esters and the effects of para-substitution in the benzenesulfonamide moiety.
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Reference：
Thiazole | C3H6290NS – PubChem,
Thiazole | chemical compound | Britannica