137-00-8, Name is 4-Methyl-5-thiazoleethanol, molecular formula is C6H9NOS, belongs to thiazole compound, is a common compound. In a patnet, once mentioned the new application about 137-00-8, HPLC of Formula: C6H9NOS
A series of 3,3?-disubstituted 5,5?-bi(1,2,4-triazine) derivatives was synthesized and screened against the erythrocytic stage of Plasmodium falciparum 3D7 line. The most potent dimer, 6k, with an IC50 (50% inhibitory concentration) of 0.008 muM, had high in vitro potency against P. falciparum lines resistant to chloroquine (W2, IC50 = 0.0047 ± 0.0011 muM) and artemisinin (MRA1240, IC50 = 0.0086 ± 0.0010 muM). Excellent ex vivo potency of 6k was shown against clinical field isolates of both P. falciparum (IC50 = 0.022-0.034 muM) and Plasmodium vivax (IC50 = 0.0093-0.031 muM) from the blood of outpatients with uncomplicated malaria. Despite 6k being cleared relatively rapidly in mice, it suppressed parasitemia in the Peters 4-day test, with a mean ED50 value (50% effective dose) of 1.47 mg kg-1 day-1 following oral administration. The disubstituted triazine dimer 6k represents a new class of orally available antimalarial compounds of considerable interest for further development.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.HPLC of Formula: C6H9NOS. In my other articles, you can also check out more blogs about 137-00-8
Reference：
Thiazole | C3H5557NS – PubChem,
Thiazole | chemical compound | Britannica