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1-(6′-Substituted-2′-benzothiazolyl)-3,4-dimethylpyrano<2,3-c>pyrazol-6(1H)-ones (3) have been synthesized (i) by the reaction of 2-hydrazino-6-substituted-benzothiazoles (1) with ethyl acetoacetate and (ii) by the reaction of 1-(6′-substituted-2′-benzothiazolyl)-3-methylpyrazol-5-ols (2) with ethyl acetoacetate.Some of the compounds (3a-c and 3e) display moderate levels of antiinflammatory activity.
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Reference：
Thiazole | C3H7056NS – PubChem,
Thiazole | chemical compound | Britannica