Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 137-00-8, C6H9NOS. A document type is Article, introducing its new discovery., Application In Synthesis of 4-Methyl-5-thiazoleethanol
Purpose: A series of novel lipid-like O- and N-(3-trimethylsilyl)propyl derivatives of N-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinoline, -tetrahydroisoquinoline and 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole have been obtained in order to facilitate penetration of biologically active small molecules through the plasma membrane and/or to enable their immobilization on the surface of magnetic nanocarriers for drug delivery application. Methods: The synthesized compounds have been characterized by 1H, 13C and 29Si NMR spectroscopy and mass-spectrometry, evaluated for cytotoxicity on monolayer human fibrosarcoma HT-1080 and mouse hepatoma MG-22A tumour cell lines and normal mouse fibroblasts NIH 3T3, and screened for antimicrobial activity against gram-positive and gram-negative bacterial and fungal strains. Their inhibitory action towards topoisomerase II has also been investigated. Results: The obtained organosilicon compounds possessed high selective cytotoxicity (LC 50<1 mug ml -1) towards tumour cells and NO-induction ability, exhibited strong antimicrobial activity with MIC and MBC/MFC values of 0.5?32 mug ml-1 for the most active ones. Conclusions: The lipid-like organosilicon derivatives of hydroxyethyl tetrahydro(iso)quinoline and thiazole exhibit an interesting combination of inhibitory activities towards tumours and bacterial cells and fungi. The pharmacological effect ranged from moderate to significant and increased upon quaternization. Compounds possessing high cytotoxicity and strong antibacterial and antifungal activity can be further developed as potential monotherapeutic agents for treatment infections in cancer patients instead of combination anticancer and anti-infective pharmacotherapy. Interested yet? Keep reading other articles of 137-00-8!, Application In Synthesis of 4-Methyl-5-thiazoleethanol
Reference：
Thiazole | C3H5445NS – PubChem,
Thiazole | chemical compound | Britannica