Synthetic Route of 82294-70-0. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 82294-70-0, Name is 4-Methylthiazole-5-carbaldehyde. In a document type is Article, introducing its new discovery.
A series of novel chalcone derivatives containing the 1,2,4-triazine moiety were synthesized and their structures were confirmed by 1H NMR, 13C NMR and elemental analyses. Antiviral bioassays revealed that most of the compounds exhibited good antiviral activity against tobacco mosaic virus (TMV) at a concentration of 500 mug mL-1. The designated compound 4l was 50% effective in terms of curative and protective activities against TMV with 50% effective concentrations (EC50) of 10.9 and 79.4 mug mL-1, which were better than those of ningnanmycin (81.4 and 82.2 mug mL-1). Microscale thermophoresis (MST) also showed that the binding of compound 4l to coat protein (TMV-CP) yielded a Kd value of 0.275 ± 0.160 mumol L-1, which was better than that of ningnanmycin (0.523 ± 0.250 mumol L-1). At the same time, molecular docking studies for 4l with TMV-CP (PDB code:1EI7) showed that the compound was embedded well in the pocket between the two subunits of TMV-CP. Meanwhile, compound 4a demonstrated excellent antibacterial activities against Ralstonia solanacearum (R. solanacearum), with an EC50 value of 0.1 mug mL-1, which was better than that of thiodiazole-copper (36.1 mug mL-1) and bismerthiazol (49.5 mug mL-1). The compounds act by causing folding and deformation of the bacterial cell membrane as observed using scanning electron microscopy (SEM). The chalcone derivatives thus synthesized could become potential alternative templates for novel antiviral and antibacterial agents.
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Reference：
Thiazole | C3H5777NS – PubChem,
Thiazole | chemical compound | Britannica