Reference of 38205-66-2. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 38205-66-2, Name is 1-(4-Thiazolyl)ethanone
Kinetic results are reported on the rates of enolisation of title compounds in water, in acetate buffers, in dilute hydrochloric acid, in dilute sodium hydroxide solutions and in the presence of several metal-ion salts, as measured by their rates of halogenation at 25 deg C.The results have been compared with those previously obtained from the corresponding reactions of acetophenone and a number of acetylheterocycles.It is shown that a suitable metal cation (e.g., Cu2+) can be hundreds of times more effective than the proton in catalysing the enolisation process of an acetylheterocyclic compound.This can be due either to the ‘soft’ character of the acetyl group, as, for example, that of 2-acetylpyrrole, or to coordination of both the carbonyl oxygen and the heteroatom by the metal cation in the transition state of the reaction, as for 2- and 4-acetylthiazoles.
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Reference：
Thiazole | C3H242NS – PubChem,
Thiazole | chemical compound | Britannica