A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 155559-81-2, Name is 5-Fluorobenzo[d]thiazole-2-thiol, molecular formula is C7H4FNS2. In a Article，once mentioned of 155559-81-2, Recommanded Product: 155559-81-2
4?-Demethylepipodophyllotoxin (DMEP) derivatives are broad-spectrum and potent antitumor leading compound. Because of their unacceptable toxicity, DMEP derivatives often failed in the development of new drug. Until now, there was no report on the millimolar-potency toxicity of DMEP derivatives by modifying the molecule structure of DMEP. For the first time, this work discovered leading compounds with millimolar-potency toxicity by modifying the molecule structure of DMEP. The IC50 value of 4beta-S-(5-fluorobenzoxazole-2-)-4-deoxy-4?-demethylepipodophyllotoxin (Compound 2) was around 323.4?2000.9 muM on human healthy cells (i.e., HL-7702, H8, MRC-5 and HMEC), which was significantly reduced by 171?1999 times than podophyllotoxin (1.0?2.6 muM) and 9?80 times than etoposide (21.5?75.4 muM). Compared with the treatment of etoposide, DNA repair proteins HMGB1 and PARK7 were specifically activated and the expression of anti-apoptotic proteins were up-regulated in HL-7702 cells after the treatment of Compound 2. These indicated the toxicity of Compound 2 was synergistically reduced by DNA repair and anti-apoptosis pathway.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Recommanded Product: 155559-81-2. In my other articles, you can also check out more blogs about 155559-81-2
Reference：
Thiazole | C3H6392NS – PubChem,
Thiazole | chemical compound | Britannica