Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 566169-93-5, Name is 2-(4-(Methylamino)phenyl)benzo[d]thiazol-6-ol, Formula: C14H12N2OS.
This work focuses on the development of specific substrates for estrogen sulfotransferase (SULT1E1) to produce molecular imaging probes for this enzyme. SULT1E1 is a key enzyme in estrogen homeostasis, playing a central role in the prevention and development of human disease. In vitro sulfation assays showed alkyl and aryl substitutions to a fused heterocyclic system modeled after beta-naphthol (betaN), based on compounds that interact with the estrogen receptor, rendered several molecules with enhanced specificity for SULT1E1 over SULT1A1*1, SULT1A1*2, SULT1A3, and SULT2A1. Several 6-hydroxy-2-arylbenzothiazoles tested demonstrated excellent affinity – V max/Km ratios – and specificity for SULT1E1. Km values ranged from 0.12-2.36 muM. A strong correlation was observed between polarity of the 4?-sustituent on the 2-aryl moiety (Hammett sigmap) and the log(Vmax/Km) (r = 0.964). Substrate sensitivity is influenced by the acidity of the 6-phenolic group demonstrated by correlating its 1H NMR chemical shift (deltaOH) with the log(V max/Km) (r = 0.963). Acidity is mediated by the electron withdrawing capacity of the 4?-substituent outlined by the correlation of the C-2 13C NMR chemical shift (deltaC2) with the log(Vmax/Km) (r = 0.987). 2-[4-(Methylamino)phenyl]-6- hydroxybenzothiazole (2b) was radiolabeled with carbon-11 (11C-(2b)) and used in vivo for microPET scanning and tissue metabolite identification. High PET signal was paralleled with the presence of radiolabeled 11C-(2b)-6-O-sulfate and the SULT1E1 protein detected by western blot. Because this and other members of this family presenting specificity for SULT1E1 can be labeled with carbon-11 or fluorine-18, in vivo assays of SULT1E1 functional activity are now feasible in humans.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Formula: C14H12N2OS. In my other articles, you can also check out more blogs about 566169-93-5
Reference：
Thiazole | C3H424NS – PubChem,
Thiazole | chemical compound | Britannica