01/9/2021 News Final Thoughts on Chemistry for 2-Ethylthiazole-4-carboxylic acid

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In an article, published in an article, once mentioned the application of 769124-05-2, Name is 2-Ethylthiazole-4-carboxylic acid,molecular formula is C6H7NO2S, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of 2-Ethylthiazole-4-carboxylic acid

Two-dimensional libraries of 4-acylamino-1,3-thiazoles 9 were prepared via Curtius rearrangement of 1,3-thiazole-4-carbonyl azides 6, trapping of the intermediate isocyanates with oxime resin, and thermal regeneration of the isocyanates from the washed resin in the presence of nucleophiles. Several compounds proved to be selective inhibitors of CDK5/p25 versus the closely homologous CDK2/cyclin A enzyme, with the best analogue (43) possessing over 100-fold selectivity.

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Reference:
Thiazole | C3H3272NS – PubChem,
Thiazole | chemical compound | Britannica