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Highly active substantially pure Z-isomers of cephalosporins are produced by the following synthesis: STR1 in which R1, R4 and R5 ae various organic radicals, R2 is alkoxycarbonyl, Y is Cl, Br or –O–SO2 –R5, and X is a conventional cephalosporin substituent. Many of the intermediates are new, especially in pure Z-form.
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Reference：
Thiazole | C3H10773NS – PubChem,
Thiazole | chemical compound | Britannica