Application of 25742-12-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 25742-12-5, Name is Thiazole-5-carbonitrile. In a document type is Article, introducing its new discovery.
SAR of lead benzothiophene H1-antihistamine 2 was explored to identify backup candidates with suitable pharmacokinetic profiles for an insomnia program. Several potent and selective H1-antihistamines with a range of projected half-lives in humans were identified. Compound 16d had a suitable human half-life as demonstrated in a human microdose study, but variability in pharmacokinetic profile, attributed to metabolic clearance, prevented further development of this compound. Compound 28b demonstrated lower predicted clearance in preclinical studies, and may represent a more suitable backup compound.
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Reference：
Thiazole | C3H9373NS – PubChem,
Thiazole | chemical compound | Britannica