The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1603-91-4, Name is 4-Methylthiazol-2-amine, molecular formula is C4H6N2S. In a Article，once mentioned of 1603-91-4, Recommanded Product: 1603-91-4
2-Cyanoacetamido-4-methylthiazole (1) was utilized as a versatile precursor for the construction of new thiazole clubbed thiazolidine, thiophene, pyridine, or chromene scaffold. The base-catalyzed addition of 1 to phenyl isothiocyanate followed by subsequent treatment of the produced thiocarbamoyl intermediate with ethyl chloroacetate or chloroacetonitrile furnished the corresponding thiazolyl-thiazolidine and thiazolyl-thiophene hybrids. The reactions of compound 1 with chemical reagents, namely, acetylacetone, malononitrile, and/or 2-(4-anisylidene)-malononitrile have been studied and furnished the corresponding thiazole-pyridine hydrides 8?10. Furthermore, treatment of the precursor 1 with salicylaldehyde, various aryl diazonium chlorides, and/or aromatic aldehydes afforded their corresponding thiazolyl-chromene hybrid 12, arylhydrazono-nitriles 13, and unsaturated nitriles 14, respectively. The cytotoxicity of the synthesized compounds was screened against the cell lines HepG2, HCT-116, and MCF-7. Compounds 8, 10, and 12 recorded the best results, which was illustrated by molecular docking. Molecular Operating Environment molecular docking calculations carried out here is to rationalize correlation between docking results and biological data of thymidylate synthase (Protein Data Bank code: IHVY) inhibition. Docking has been carried out in the same co-crystallographic inhibitor binding site to predict if the binding mode of active compounds is analogous to that of native inhibitor.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 1603-91-4, you can also check out more blogs about1603-91-4
Reference：
Thiazole | C3H9950NS – PubChem,
Thiazole | chemical compound | Britannica