Application of 3581-87-1. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 3581-87-1, Name is 2-Methylthiazole
We herein report the discovery of a new gamma-secretase modulator class with an aminothiazole core starting from a HTS hit (3). Synthesis and SAR of this series are discussed. These novel compounds demonstrate moderate to good in vitro potency in inhibiting amyloid beta (Abeta) peptide production. Overall c-secretase is not inhibited but the formation of the aggregating, toxic Abeta42 peptide is shifted to smaller non-aggregating Ab peptides. Compound 15 reduced brain Abbeta42 in vivo in APPSwe transgenic mice at 30 mg/kg p.o.
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Reference：
Thiazole | C3H3628NS – PubChem,
Thiazole | chemical compound | Britannica