Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1017781-60-0, Name is 4-(4-Bromothiazol-2-yl)morpholine, Application In Synthesis of 4-(4-Bromothiazol-2-yl)morpholine.
A series of thiazole-based inhibitors selectively targeting DNA-binding domain of the androgen receptor (AR) were synthesized and evaluated, and the SAR data were summarized. We identified a novel compound SKLB-C2807 that effectively inhibited the human prostate cancer cell line LNCaP/AR with the IC50 value of 0.38 mum without significant antiproliferative effects on other cell lines PC-3 (AR-negative), SW620, MCF-7 (ER-positive), and L-O2 (non-cancerous). This compound also considerably decreased the expression of prostate-specific antigen. Its binding mode to the AR-DBD was studied. These efforts lay the foundation for developing the next generation of anti-androgens.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application In Synthesis of 4-(4-Bromothiazol-2-yl)morpholine. In my other articles, you can also check out more blogs about 1017781-60-0
Reference：
Thiazole | C3H4684NS – PubChem,
Thiazole | chemical compound | Britannica