A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 39893-80-6, Name is 4-(3,4-Dichlorophenyl)thiazol-2-amine, molecular formula is C9H6Cl2N2S. In a Article,once mentioned of 39893-80-6, name: 4-(3,4-Dichlorophenyl)thiazol-2-amine
In this paper we describe the synthesis, structure-activity relationship (SAR), and biochemical characterization of N-(4-phenylthiazol-2- yl)benzenesulfonamides as inhibitors of kynurenine 3-hydroxylase. The compounds 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide 16 (IC50 = 37 nM, Ro-61-8048) and 4-amino-N-[4-[2-fluoro-5- (trifluoromethyl)phenyl]-thiazol-2-yl]benzenesulfonamide 20 (IC50 = 19 nM) were found to be high-affinity inhibitors of this enzyme in vitro. In addition, both compounds blocked rat and gerbil kynurenine 3-hydroxylase after oral administration, with ED50’s in the 3-5 mumol/kg range in gerbil brain. In a microdialysis experiment in rats, 16 dose dependently increased kynurenic acid concentration in the extracellular hippocampal fluid. A dose of 100 mumol/kg po led to a 7.5-fold increase in kynurenic acid outflow. These new compounds should allow detailed investigation of the pathophysiological role of the kynurenine pathway after neuronal injury.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.name: 4-(3,4-Dichlorophenyl)thiazol-2-amine, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 39893-80-6, in my other articles.
Reference:
Thiazole | C3H4659NS – PubChem,
Thiazole | chemical compound | Britannica