9/22 News New explortion of 5-Thiazolamine hydrochloride

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In an article, published in an article, once mentioned the application of 942631-51-8, Name is 5-Thiazolamine hydrochloride,molecular formula is C3H5ClN2S, is a conventional compound. this article was the specific content is as follows.category: thiazole

Herein we report the discovery of a novel series of phosphodiesterase 10A inhibitors. Optimization of a HTS hit (17) resulted in potent, selective, and brain penetrant 23 and 26; both exhibited much lower clearance in vivo and decreased volume of distribution (rat PK) and have thus the potential to inhibit the PDE10A target in vivo at a lower efficacious dose than the reference compound WEB-3.

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Reference:
Thiazole | C3H6652NS – PubChem,
Thiazole | chemical compound | Britannica