With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2941-58-4,2-Bromo-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.
2-Bromo-6-methoxybenzo [d] thiazole (555 mg, 2.28 mmol) was dissolved in methylene chloride (10 mL) at room temperature under an argon atmosphere. To the resulting solution, 1 M boron tribromide methylene chloride solution (4 mL) was added at room temperature. The resulting mixture was stirred under an argon atmosphere at room temperature for 7 hours.The reaction mixture was added to ice water and then extracted with chloroform (3 × 30 mL). The combined organic layer was dried over anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (silica gel 80 g; hexane: ethyl acetate (3: 1)) to give 2-bromobenzo [d] thiazol-6-ol (521 mg, yield 99 %) As a brown solid. The measured physical properties of the product are as follows., 2941-58-4
2941-58-4 2-Bromo-6-methoxybenzothiazole 11218765, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; KEIO UNIVERSITY; SAITOH, TSUYOSHI; NISHIYAMA, SHIGERU; IOKA, SHUJI; MAKI, SHOJIRO; NIWA, HARUKI; (19 pag.)JP6095208; (2017); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica