With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-53-5,2-Bromothiazole,as a common compound, the synthetic route is as follows.
The (4-formylphenyl)boronic acid 118 (0.30 g, 2.0 mmol), 2-bromo-l,3-thiazole 119a (0.33 g, 2.0 mmol), Pd(PPh3)4(0.12 g, 0.1 mmol), aqueous solution of potassium carbonate (0.4 M, 5 mL), ethanol (5 mL) and toluene (2mL) were added to a 50 mL flask under nitrogen. The reaction mixture was stirred at 115 C for 24 hours and then cooled to room temperature. After removing the solvent, the crude residue was purified by column chromatography on silica gel using EA/hexane (1/5) as eluent. The product 120a was obtained as a white solid at a yield of 95%.
3034-53-5, 3034-53-5 2-Bromothiazole 76430, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; SHIH, Chuan; NATIONAL HEALTH RESEARCH INSTITUTES; ACADEMIA SINICA; CHEN, Chih-Hao; CHEN, Chiung-Tong; WANG, Hwei-Jiung; HUANG, Kai-Fa; (130 pag.)WO2020/47360; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica