With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.118452-02-1,2-Aminothiazole-4-carboxamide,as a common compound, the synthetic route is as follows.
To a solution of 2-(S)-(2-tert-butoxycarbonylamino-2-phenyl-acetylamino)-3-phenyl-propionic acid (239 mg, 0.6 mmol) and 2-amino-thiazole-4-carboxylic acid amide (71.5 mg, 0.5 mmol) in N,N-dimethylformamide (5 mL) was added diisopropylethylamine (174 muL, 9.99 mmol) and O-benzotriazol-1-yl-N,N,N’,N’-tetramethyluronium hexaflurorophosphate (455 mg, 1.2 mmol) and the mixture stirred at ambient temperature overnight. The reaction was quenched with saturated aqueous ammonium chloride solution (10 mL), the mixture poured into water (50 mL) and extracted with ethyl acetate (3×20 mL). The combined organic extracts were washed with water (3×10 mL), brine (20 mL), dried over sodium sulfate and concentrated in vacuo. The residue was purified by chromatography over silica gel eluted with ethyl acetate to give {[1-((S)-4-carbamoyl-thiazol-2-ylcarbamoyl)-2-phenyl-ethylcarbamoyl]-phenyl-methyl}-carbamic acid tert-butyl ester as a glassy solid (31 mg, 12%). LR-MS: Obs. Mass, 524.25. Calcd. Mass, 524.1967 (M+H)., 118452-02-1
As the paragraph descriping shows that 118452-02-1 is playing an increasingly important role.
Reference：
Patent; Goodnow,, Robert Alan; Huby, Nicholas J.S.; Kong, Norman; McDermott, Lee Apostle; Moliterni, John Anthony; Zhang, Zhuming; US2006/63814; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica