Day: March 9, 2022

3034-53-5, 2-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Substrate (0.1 mmol) and catalyst (2 mol%, 2 mumol) were mixed in 3 cm3 THF, organomagnesium reagent(1.3 mmol) was added at room temperature. After 6 h at 60 C, 1.5 cm3 NaCl solution (15%) was added carefully, the organic layer was dried over MgSO4, evaporated and purified via silica column chromatography.

3034-53-5, As the paragraph descriping shows that 3034-53-5 is playing an increasingly important role.

Reference：
Article; Mastalir, Mathias; Kirchner, Karl; Monatshefte fur Chemie; vol. 148; 1; (2017); p. 105 – 109;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14542-13-3,2-Methoxythiazole,as a common compound, the synthetic route is as follows.,14542-13-3

To a stirred solution of compound 606-13a (20.0 g, 174 mmol) in anhydrous THF (700 mL) was added n-BuLi (2.5 M solution in hexanes, 70 mL, 175 mmol) dropwise over 20 min at -78 C (dry ice/acetone bath) under nitrogen. The resulting reaction mixture was stirred at -78 C under N2 for 2 h. After this time, I2 (44.2 g, 174 mmol) was added. The resulting mixture was slowly warmed to rt over 2 h and stirred at rt for 1 h. The reaction mixture was then cooled to 0 C and quenched by slow addition of saturated NH4Cl aqueous solution (300 mL). The resulting mixture was warmed to rt and extracted with EtOAc (500 mL). The extract was washed with 20% Na2S203 aqueous solution (300 mL) and brine (300 mL), dried over anhydrous Na2S04, filtered, and concentrated under reduced pressure (The product is volatile; evaporator bath temperature chromatography on silica gel eluting with 5% EtO Ac/hexanes (The product is volatile; evaporator bath temperature

As the paragraph descriping shows that 14542-13-3 is playing an increasingly important role.

Reference：
Patent; AGENEBIO, INC.; MEKONNEN, Belew; BUTERA, John, A.; HUANG, Jianxing; PATEL, Hemantbhai; JIANG, Qin; HERR, Robert, Jason; MAYHEW, Nicholas, James; FREEMAN, Emily, Elizabeth; (682 pag.)WO2019/246300; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

6294-52-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6294-52-6,5,6-Dimethoxybenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

To the reaction mixture of 5,6-dimethoxybenzo[d]thiazol-2-amine (50 mg, 0.238 mmol), TEA (0.100 mL, 0.713 mmol) in DCM (1 mL) was added 2-chloroacetyl chloride (0.023 mL, 0.285 mmol) at room temperature. Overnight, concentration and purification on combiflash (4 g, MeOH/DCM) gave 2-chloro-N-(5,6-dimethoxybenzo[d]thiazol-2-yl)acetamide (15 mg, 0.052 mmol, 22.00% yield). 1HNMR (400 MHz, CDCl3), 9.73 (s, 1H), 7.26 (s, 1H), 7.25 (s, 1H), 4.30 (s, 2H), 3.969s, 6H) ESI-MS: m/z 286.94 (M+H)+

As the paragraph descriping shows that 6294-52-6 is playing an increasingly important role.

Reference：
Patent; Stingray Therapeutics, Inc.; Vankayalapati, Hariprasad; Sharma, Sunil; Kaadige, Mohan Rao; Weston, Alexis; Thode, Trason; (117 pag.)US2020/39979; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

921927-88-0, Methyl 2-formylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

921927-88-0, Lithium diisopropyl amide (?LDA,? 60 mL, 108 mmol, 1 .8M) was added to 200 mL of ether at -78 C. followed by the addition of sulfinimine 7 (18.9 g, 100 mmol) in 200 mLether and the resultant reaction mixture was stirred for 40 mi C1Ti(OiPr)3 (203 mmol, 48.4 mL) was added to the reaction mixture and the solution was stirred for 60 mm. A solution of methyl 2-formylthiazole-4-carboxylate 4 (12.5 g, 72.6 mmol) in 180 mL of THF was added slowly to thereaction mixture. Afier another 2 h at -78 C., a mixture of acetic acid and THF (?A v/v, 4.9 mL) was added. The mixturewas warmed to 5 C. over 1 h and then poured into brine solution. The desired product was then extracted from the brine solution with ether and EtOAc solution. The organic phase was then dried over anhydrous MgSO4, filtered and evaporated. The residue was passed through 2 columns (DCM:EtOAc and hexane:EtOAc) to give compound 8 (19.6 g, 54 mmol, 75%) as an oil. MS (ES+) mlz, calculated: m+1, 361.12. found, 361.

The synthetic route of 921927-88-0 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; E. R. SQUIBB & SONS, L.L.C.; Cheng, Heng; Gangwar, Sanjeev; Cong, Qiang; (82 pag.)US9226974; (2016); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.,3622-35-3

Tert-butyl (2S,3R)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-ylcarbamate (6.2) (31.0 g) in dichloromethane was added to a solution of benzothiazole-6-carboxylic acid (1.05 eq), triethylamine (1.5 eq) and HATU (2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, 1.05 eq) in dichloromethane (500 mL). The reaction mixture was stirred at room temperature overnight. Water was added and the phases were separated. The organic phase was three times washed with a saturated aqueous Na2CO3 solution, brine, dried with MgSO4 and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: dichloromethane dichloromethane/methanol 95:5) to afford compound 6.3 quantitative.

3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; TIBOTEC BVBA; US2010/305073; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica