With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.209459-11-0,Methyl 2-aminobenzo[d]thiazole-7-carboxylate,as a common compound, the synthetic route is as follows.
A.4.3 Synthesis of benzothiazole-7-carboxylic acid methyl ester; Isoamyl nitrite (22.0 mmol) is added to a solution of 2-amino-benzothiazole-7-carboxylic acid methyl ester (10.1 mmol) in THF (29 mL). The mixture is heated to reflux for 4h, the solvents are removed in vacuo and the residue is purified by flash chromatography (gradient: heptane to EtOAc/heptane 4/6) to give the desired product. LC-MS: tR = 0.85 min; [M+H]+ = 194.0.
209459-11-0, 209459-11-0 Methyl 2-aminobenzo[d]thiazole-7-carboxylate 10910742, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/104155; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica