Day: March 11, 2022

59418-09-6, Methyl 4-thiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,3-bis(dicyclohexylphosphino)propane (dcypp: 20.0 mol%, 21.9mg) was dissolved in o-dichlorobenzene (1.0 mL) in a two-necked flask equipped under argon atmosphere. Then, RhH(CO)(PPh3)3 (10.0 mol%, 23.0 mg), 4-phenylthiazole 1a (0.25 mmol, 40.3 mg)and 2-methylthiothiazole 5 (0.75 mmol, 78 L) were added to the solution, and the mixture was heated at reflux for 3 h. Then, the solvent was removed under reduced pressure, and the residue was purified byflash columm chromatography on silica gel giving 2-(methylthio)-4-phenylthiazole 3a (38.5 mg, 74%). 3a11, 59418-09-6

As the paragraph descriping shows that 59418-09-6 is playing an increasingly important role.

Reference：
Article; Arisawa, Mieko; Nihei, Yuri; Yamaguchi, Masahiko; Heterocycles; vol. 90; 2; (2015); p. 939 – 949;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

939-69-5, 6-Hydroxybenzo[d]thiazole-2-carbonitrile is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

939-69-5, Example 4 Synthesis of Compounds 4 and 13 2-Cyano-6-t-butyldiphenylsiloxy-benzothiazole. A solution of 2-cyano-6-hydroxybenzothiazole (5.0 g, 28 mmol) in 100 ml of anhydrous DMF under inert atmosphere was treated with 2.9 g of imidazole (4.2 mmol) followed by t-butyldiphenylchlorosilane (9.34 g, 34 mmol). The reaction was stirred at room temperature for 3 h and then diluted with 200 ml of ethyl acetate and washed with water (4*400 ml). The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography, eluding with 5-10percent ethyl acetate/hexanes to afford 13.0 g of the desired product containing ~10percent silyl impurity in quantitative yield. The product was taken on without further purification. 1 H NMR (CDCl3): delta 1.12 (s, 9H); 7.13-7.46 (m, 8H); 7.70-7.72 (m, 4H); 7.92-7.95 (d, 1H).

The synthetic route of 939-69-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Lumigen, Inc.; US6045991; (2000); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 114 – preparation of N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)benzo[d]thiazole-6-carboxamide[00151] HATU (695 mg, 1 .83 mmol) was added to Compound 2 (400 mg, 1 .41 mmol), benzo[d]thiazole-6-carboxylic acid (290 mg, 1 .62 mmol) and DIPEA (0.737 mL, 4.22 mmol) in DMA (15 mL) and the resultant mixture stirred at ambient temperature for 16 hours under an inert atmosphere. The reaction mixture was diluted with EtOAc (300 mL), and washed with water (2 x 200 mL). The organic layer was dried over Na2S04, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 20 to 100% EtOAc in isohexane. The pure fractions were evaporated to a yellow solid which was triturated with DCM and filtered to afford the desired material as a white solid (287 mg, 46 %). 1H NMR (400 MHz, DMSO) delta 10.05 (s, 2H), 9.57 (s, 1 H), 8.82 (d, J= 1 .5 Hz, 1 H), 8.23 (d, J= 8.5 Hz, 1 H), 8.15 (dd, J = 1 .74, 8.6 Hz, 1 H), 7.87 (d, J = 2.1 Hz, 1 H), 7.58 – 7.65 (m, 1 H), 7.47 – 7.57 (m, 2H), 7.24 (d, J= 8.42 Hz, 1 H), 6.98 (d, J= 8.37 Hz, 1 H), 4.32 (m, 4H), 2.24 (s, 3H). m/z (ES+), (M+H)+ = 446.

3622-35-3, The synthetic route of 3622-35-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2941-58-4, 2-Bromo-6-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In an 8 mL screw cap vial was added a solution of 3-benzyl-6-mercapto-5- [METHYL-LH-PYRIMIDINE-2,] 4-dione, (0.025 g, 0.1 mmol) in dimethylformamide (1 [ML),] a solution of 2-bromo-6-methoxybenzothiazole (0.15 mmol) in dimethylformamide (0.3 mL) and diisopropylethylamine (0.05 mL, 0.3 mmol). The vial was capped and the reaction mixture was shaken for 24 hours at [100C.] The solvent was removed under vacuum. Purification was carried out via reverse- phase HPLC (ODS AC-18, [5] [T,] 30 mm [X100] mm, 3% n-propanol in acetonitrile and [3%] n-propanol in water 10 % to [90%] over 10 minutes) to give 3-benzyl-6- (6- [METHOXY-BENZOTHIAZOL-2-YLAMINO)-5-METHYL-1H-PYRIMIDINE-2,] 4-dione. MS [(APCI),] m/z [( [M+H] +)] 395.1.

2941-58-4, The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/14868; (2004); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2941-58-4,2-Bromo-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

To a stined solution of 2-bromo-6-methoxybenzo[d]thiazole (8.00 g, 32.8 mmol) in dichloromethane (20 mL) at 15 C was added tribromoborane (9.1 mL, 98 mmol) dropwise. The resulting mixture was heated at 40 C for 6 h then poured into ice water. The precipitate was filtered and the filtrate was extracted with dichloromethane (40 mL x 3). The precipitate and the organic layers were combined, dried over Na2504,and concentratedto give the title compound.MS: m/z = 229.9, 231.9 (M + 1). ?H NMR (400 MHz, CD3OD): oe7.74 (d, J= 8.8 Hz, 1H), 7.28 (d,J=2.4Hz, 1H),7.00(dd,J,=8.8Hz, J2=2.4Hz, 1H)., 2941-58-4

The synthetic route of 2941-58-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SHARP & DOHME CORP.; STUMP, Craig A.; CHEN, Yi Heng; LIU, Ping; MENG, Dongfang; WU, Jane; LI, Chun Sing; QI, Zhiqi; (163 pag.)WO2016/161572; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica