Day: March 14, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31785-05-4,Ethyl 5-amino-2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

B) A-amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (0.15 g, 0.806 mmol), cyclopropancarboxaldehyde (0.23 g, 3.29 mmol) was treated with cyclopropanecarboxaldehyde (0.230 g, 3.22 mmol) and tetraisopropyl-orthotitanate (0.916 g, 3.22 mmol) and stirred at room temperature overnight. Ethanol (5 mL) and sodium cyanoborohydride (0.213 g, 3.22 mmol) were added and the reaction mixture was stirred for 5 h. Water (0.5 mL) was added to the reaction mixture and the solvent was evaporated. The residue was purified by flash chromatography on silica gel with ethyl acetate/methanol 100:0?90:10 gradient to yield 5-((cyclopropylmethyl)-amino)-2-methyl-thiazole-4-carboxylic acid isopropyl ester (0.170 g, 83%) as a yellow oil

31785-05-4, The synthetic route of 31785-05-4 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric; US2006/160857; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.425392-45-6,Ethyl 5-chlorothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

0.56 g of ethyl mercaptan sodium salt (80%) was added to a mixture of 0.86 g of 5-chlorothiazole-4-carboxylic acid ethyl ester, 3 ml of DMF and 1 ml of THF, under ice cooling, and then the mixture was stirred at room temperature for 1 hour. Water was poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.71 g of 5-ethylsulfanylthiazole-4-carboxylic acid ethyl ester., 425392-45-6

425392-45-6 Ethyl 5-chlorothiazole-4-carboxylate 58758599, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Nokura, Yoshihiko; Ito, Mai; Shimizu, Chie; Mizuno, Hajime; US2015/94329; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A compound of Formula P-1 is treated with, for example, potassium thiocyanate and bromine in acetic acid to produce a compound of Formula P-2. The compound of Formula P-2 is treated with an acetylating reagent such as acetyl chloride to produce a compound of Formula P-3. The compound of P-3 is reacted with, for example, bis(pinacolato)diboron (compound P-4) in the presence of a catalyst such as palladium chloride to produce a compound of Formula P-5.

15864-32-1, The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; INTELLIKINE, LLC; LIU, Yi; REN, Pingda; JESSEN, Katayoun; GUO, Xin; ROMMEL, Christian; WILSON, Troy, Edward; WO2014/151147; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

64987-16-2, Methyl 2-(2-aminothiazol-4-yl)acetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a 250 mL three-neck flask, copper cyanide (7.28 g, 80 mmol) was successively added.Anhydrous acetonitrile (30mL),Tert-butyl nitrite(10 mL, 80 mmol),Raise the temperature to 50CA solution of 2-(2-aminothiazol-4-yl)acetic acid ethyl ester (7.5 g, 40 mmol) in anhydrous acetonitrile (20 mL) was added dropwise, and the addition was completed within 1 h and the reaction was continued for 2.5 h. The solvent is distilled off under reduced pressureThe crude product was purified by column chromatography (petroleum ether/ethyl acetate (V/V) = 25/1) to give a slightly yellow liquid (2 g, 25%)., 64987-16-2

As the paragraph descriping shows that 64987-16-2 is playing an increasingly important role.

Reference：
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhang Yingjun; Ren Qingyun; Liu Xinchang; Wang Chaolei; S ·geerdeman; (80 pag.)CN103664897; (2018); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-53-5,2-Bromothiazole,as a common compound, the synthetic route is as follows.

In the reaction vessel, 0.02 mol of K4[Fe(CN)6], a designed amount of CuI, and 50 mL of N-methylimidazole were sequentially added, and the temperature was raised to the designed temperature, and 0.1 mol of the injection pump was slowly added while stirring. 2-Bromothiazole, after the addition was completed, stirring was continued, and the reaction temperature was kept constant under nitrogen protection.After the reaction is completed, the temperature is lowered to room temperature, 50 mL of H 2 O is added, and then the organic solvent layer is extracted with a selected organic solvent (3×100 mL), the temperature is lowered to 0 C., concentrated hydrochloric acid is added until pH=2 to 3, and then the aqueous layer of hydrochloric acid is used. Extraction by organic solvent extraction (3 x 50 mL), combining all organic solvent layers, and then steaming to give 2-cyanothiazole. The target product is detected by nuclear magnetic resonance, and the hydrogen spectrum carbon spectrum of the target product is as follows:, 3034-53-5

The synthetic route of 3034-53-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Bai Dongyue; (8 pag.)CN109369563; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica