With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31785-05-4,Ethyl 5-amino-2-methylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
B) A-amino-2-methyl-thiazole-4-carboxylic acid ethyl ester (0.15 g, 0.806 mmol), cyclopropancarboxaldehyde (0.23 g, 3.29 mmol) was treated with cyclopropanecarboxaldehyde (0.230 g, 3.22 mmol) and tetraisopropyl-orthotitanate (0.916 g, 3.22 mmol) and stirred at room temperature overnight. Ethanol (5 mL) and sodium cyanoborohydride (0.213 g, 3.22 mmol) were added and the reaction mixture was stirred for 5 h. Water (0.5 mL) was added to the reaction mixture and the solvent was evaporated. The residue was purified by flash chromatography on silica gel with ethyl acetate/methanol 100:0?90:10 gradient to yield 5-((cyclopropylmethyl)-amino)-2-methyl-thiazole-4-carboxylic acid isopropyl ester (0.170 g, 83%) as a yellow oil
31785-05-4, The synthetic route of 31785-05-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric; US2006/160857; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica