With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.425392-45-6,Ethyl 5-chlorothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
0.56 g of ethyl mercaptan sodium salt (80%) was added to a mixture of 0.86 g of 5-chlorothiazole-4-carboxylic acid ethyl ester, 3 ml of DMF and 1 ml of THF, under ice cooling, and then the mixture was stirred at room temperature for 1 hour. Water was poured to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, then dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.71 g of 5-ethylsulfanylthiazole-4-carboxylic acid ethyl ester., 425392-45-6
425392-45-6 Ethyl 5-chlorothiazole-4-carboxylate 58758599, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; Nokura, Yoshihiko; Ito, Mai; Shimizu, Chie; Mizuno, Hajime; US2015/94329; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica