Day: March 15, 2022

3034-53-5, 2-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) 4-(thiazol-2-yl)benzaldehyde 2-Bromothiazole (0.538 ml, 6.06 mmol), 4-formylphenylboronic acid (1.0 g, 6.67 mmol), and Na2CO3 (1.61 g) were suspended in the mixed solution of toluene (25 ml), ethanol (5 ml), and H2O (5 ml). The mixture was stirred at room temperature for 15 minutes under an argon gas atmosphere. After reducing the pressure inside of the reaction container by using a vacuum line, the mixture was degassed by introducing Ar gas and this procedure was repeated twice. After that, tetrakis(triphenylphosphine)palladium (0.701 g, 0.606 mmol) was added, and the mixture was stirred for 15 hours by heating under reflux. The end point of the reaction was confirmed on TLC (EtOAc:n-hexane=1:4), and the mixture was cooled to room temperature. H2O (50 ml) and EtOAc (50 ml) were added and the mixture was stirred for 15 minutes. Black insoluble matter was removed by filtration with Celite and the filtrate was separated by the step of extraction/separation. The organic layer was washed with saturated brine (50 ml) and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The resulting residue was purified on silica gel column chromatography (EtOAc:hexane=1:3) to obtain the title compound (985 mg) as an opaque white solid., 3034-53-5

3034-53-5 2-Bromothiazole 76430, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; MEIJI SEIKA PHARMA CO., LTD.; YOSHIDA, Satoshi; NINOMIYA, Tomohisa; US2013/217663; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101080-15-3,5-Isopropylthiazol-2-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 6 Preparation of a Compound of Formula (VI): 4-nitrophenyl-5-isopropyl-1,3-thiazol-2-ylcarbamate To a solution of 4 g (28.13 mmol) of 5-isopropyl-2-amino-1,3-thiazole in 30 ml of anhydrous dichloromethane 5.7 g (28.13 mmol) of 4-nitrophenyl chloroformate were added dropwise at 0 C. under nitrogen. Then 2.3 ml of pyridine were added. The mixture was maintained at room temperature under stirring overnight and then filtered, giving 6.96 g (80% yield) of the title compound as a white solid. m.p. 157-159 C. 1H-NMR (400 MHz-DMSO-d6) deltappm: 1.23 (d, 6H, J=6.8, CH3CHCH3); 3.06 (m, 1H, CH3CHCH3); 7.05 (s, 1H, H thiazole); 6.91 (d, 2H, J=9.2, H-3′, 5′-phenyl); 8.10 (d, 2H, J=9.2, H-2′,6′-phenyl); 11.00 (bs, 1H, NH). EI-MS: m/z 307 (0.5, M+); m/z 168 ((CH3)2-CH-thiazole-NCO)+; m/z 153 (100, (CH3-CH-thiazole-NCO)+); m/z 139 (45, (OH-C6H4-NO2)+)., 101080-15-3

101080-15-3 5-Isopropylthiazol-2-amine 10486954, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Pevarello, Paolo; Amici, Raffaella; Traquandi, Gabriella; Villa, Manuela; Vulpetti, Anna; Isacchi, Antonella; US2003/187040; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Preparation of n-(6-Bromo-benzothiazol-2-yl)-acetamide A mixture of 6-bromo-benzothiazol-2-ylamine (3.0 g, 13 mmol), Ac2O (1.6 g, 16.5 mmol) and DMAP (2.4 g, 19.5 mmol) in CH2Cl2 (50 mL) was stirred at room temperature for 1 hr. Then the mixture was washed with HCl (2M), saturated Na2CO3, then brine and dried over Na2SO4. The CH2Cl2 phase was evaporated to give n-(6-Bromo-benzothiazol-2-yl)-acetamide (2.5 g, yield 71%) as a white solid., 15864-32-1

15864-32-1 2-Amino-6-bromobenzothiazole 85149, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Heald, Robert; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Waszkowycz, Bohdan; US2012/202785; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42270-37-1,2-(Piperazin-1-yl)thiazole,as a common compound, the synthetic route is as follows.

(2) N-(4-((4-(Thiazol-2-yl)piperazin-1-yl)methyl)phenylmethyl)acetamide Hydrochloride 1/2 Hydrate A solution of N-(4-chloromethylphenylmethyl)acetamide(1.8 g), 1-(thiazol-2-yl)piperazine (1.5 g) and potassium carbonate (1.8 g) in dimethylformamide (20 ml) was stirred at 80 C. for 2.5 hr. The reaction mixture was poured into water (100 ml) and extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give a brown oil. The obtained brown oil was purified by silica gel column chromatography (developing solvent; chloroform_methanol=9:1) to give a pale-brown oil (2.3 g). The obtained pale-brown oil was dissolved in ethanol (200 ml) and 1M hydrogen chloride-ether (7 ml) was added. The solvent was evaporated under reduced pressure. The obtained residue was crystallized from ethyl acetate:ethanol (1:1, 100 ml) and the crystals were recrystallized from ethyl acetate:ethanol:methanol (1:1:1, 100 ml) to give the title compound (1.2 g) as white crystals, m.p.=120-121 C. 1H-NMR(DMSO-d6)delta: 1.89(3H, s), 3.00-3.35(4H, m), 3.50-3.65(2H, m), 3.70-3.80(4H, m), 3.90-4.10(2H, m), 4.28(2H, d, J=5.9 Hz), 4.35(2H, s), 6.99(1H, d, J=4.0 Hz), 7.24(1H, d, J=4.0 Hz), 7.32(1H, d, J=7.9 Hz), 7.61(1H, d, J=7.9 Hz), 8.48(1H, t, J=5.9 Hz), 11.86(1H, brs); IR(KBr): 3311, 2526, 2507, 1641, 1521 cm-1; MS(EI): 330(M+); Elemental analysis: Calculated: C; 54.32, H; 6.44, N; 14.90; Found: C; 54.10, H; 6.31, N; 14.73.

42270-37-1, As the paragraph descriping shows that 42270-37-1 is playing an increasingly important role.

Reference：
Patent; Mitsubishi Pharma Corporation; US6455528; (2002); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

96929-05-4, 33.5 g (0.18 mol) of thiazolyl ester are dissolved in 140 ml of methanol and 3 ml of water and, at 5-10 C., ammonia is introduced until the solution is saturated. The reaction mixture is stirred at room temperature overnight. The solvent is evaporated and the residue is, at 80 C., taken up in 100 ml of n-butanol. The mixture is cooled to 0 C. The precipitate is filtered off with suction, washed twice with in each case 35 ml of n-butanol and twice with in each case 35 ml of MTBE and dried under reduced pressure. Yield 17.3 g (58%), yield corrected for purity: 55% based on the thiazolidine employed. 1H-NMR (DMSO-d6): delta=8.2 (s, 1H, SCHCOOEt), 7.6, 7.7, 7.8 (3*s, 3*1H, 3*NH), 4.4 (s, 2H, CH2NH), 1.4 (s, 9H, tert-butyl) ppm.

As the paragraph descriping shows that 96929-05-4 is playing an increasingly important role.

Reference：
Patent; Abbott GmbH & Ci, KG; US6639081; (2003); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica