With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101080-15-3,5-Isopropylthiazol-2-amine,as a common compound, the synthetic route is as follows.
EXAMPLE 6 Preparation of a Compound of Formula (VI): 4-nitrophenyl-5-isopropyl-1,3-thiazol-2-ylcarbamate To a solution of 4 g (28.13 mmol) of 5-isopropyl-2-amino-1,3-thiazole in 30 ml of anhydrous dichloromethane 5.7 g (28.13 mmol) of 4-nitrophenyl chloroformate were added dropwise at 0 C. under nitrogen. Then 2.3 ml of pyridine were added. The mixture was maintained at room temperature under stirring overnight and then filtered, giving 6.96 g (80% yield) of the title compound as a white solid. m.p. 157-159 C. 1H-NMR (400 MHz-DMSO-d6) deltappm: 1.23 (d, 6H, J=6.8, CH3CHCH3); 3.06 (m, 1H, CH3CHCH3); 7.05 (s, 1H, H thiazole); 6.91 (d, 2H, J=9.2, H-3′, 5′-phenyl); 8.10 (d, 2H, J=9.2, H-2′,6′-phenyl); 11.00 (bs, 1H, NH). EI-MS: m/z 307 (0.5, M+); m/z 168 ((CH3)2-CH-thiazole-NCO)+; m/z 153 (100, (CH3-CH-thiazole-NCO)+); m/z 139 (45, (OH-C6H4-NO2)+)., 101080-15-3
101080-15-3 5-Isopropylthiazol-2-amine 10486954, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; Pevarello, Paolo; Amici, Raffaella; Traquandi, Gabriella; Villa, Manuela; Vulpetti, Anna; Isacchi, Antonella; US2003/187040; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica