With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119778-44-8,4-Ethyl-2-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.
EXAMPLE 6 (Compound No. 6) To a solution of imidazole (2.72 g; 40 mmol) in dry tetrahydrofuran (60 ml) was added dropwise thionyl chloride (1.20 g; 10 mmol) under ice-cooling while stirring. After the resultant mixture was turned to room temperature, 2-methyl-4-ethyl-5-thiazolecarboxylic acid (1.65 g; 10 mmol) was added thereto at once, and stirring was continued for 30 minutes. To the mixture was added dropwise a solution of 2-(2-thienyl)aminoacetonitrile (1.65 g; 12 mmol) in dry tetrahydrofuran under ice-cooling, and the resultant mixture was stirred at room temperature for 1 hour. After completion of the reaction, tetrahydrofuran was removed under reduced pressure to separate the residue. Water was added to the residue, which was extracted with ethyl acetate. The ethyl acetate layer was washed with water twice, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give crude oil. The oil was purified by silica-gel column chromatography (eluent:n-hexane:ethyl acetate=2:1 volume) to give crude crystals. Recrystallization from n-hexane/ethyl acetate gave 1.74 g of 2-(2-methyl-4-ethylthiazole-5-carboxamido)-2-(2-thienyl)acetonitrile as colorless crystals. m.p., 137-138 C. Yield, 60%., 119778-44-8
119778-44-8 4-Ethyl-2-methylthiazole-5-carboxylic acid 14648765, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; Sumitomo Chemical Company Limited; US4918089; (1990); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica