With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-53-5,2-Bromothiazole,as a common compound, the synthetic route is as follows.
0.15mol containing a solution of 2-bromothiazole added dropwise to a solution containing 0.18mol butyllithium was added dropwise for about 2h, after the addition was completed, stirring was continued for 1h, maintained at low temperature (-78 deg.] C) reaction carried out under . 0.3mol ethyl acetate and then added to the solution dropwise addition was completed, stirring was continued for 3h, the reaction is complete, the organic phase extracted was allowed to stand, washed with distilled water, dried over anhydrous Na2SO4 was added, and then distilled under reduced pressure collecting bp89 ~ 91 / 1.6kPa fraction, 2-acetyl thiazole 18.16g. The yield was 95.2%., 3034-53-5
3034-53-5 2-Bromothiazole 76430, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; Wutong Aroma Chemicals Co. Ltd.; Li, Xin; Sun, Bin; Wei, Jie; Wang, Xiaodong; Zhao, Leizhen; Zang, Chuanjin; Zi, Yanyan; Liu, Yuanwu; Gao, Ming; (8 pag.)CN105348216; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica