With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
96929-05-4, Compound 25 (13.47g, 47mmol) dissolved in ethanol (100 ml), lithium hydroxide (2.256g, 94mmol) aqueous solution (50 ml), stirring 6h decompression after ethanol turns on lathe , residue diluted with water, the ice-bath using 1M hydrochloric acid the pH is adjusted to 2 the […] 3, ethyl acetate extraction of the organic phase (150mLx3), combined with the phase, the organic phase with saturated salt water washing, dry anhydrous sodium sulfate, concentrated to obtain white solid compound 26 (12.13g, 100%).
The synthetic route of 96929-05-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences; JIANG, SHENG; TU, ZHENGCHAO; LI, XIANLIN; YAO, YIWU; QIU, YATAO; (24 pag.)CN103601742; (2016); B;,
Thiazole | C3H3NS – PubChem
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