Day: March 17, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.96929-05-4,Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

96929-05-4, Asolution of HCl (4 M) in dioxane was added to the protected amino compound and the mixture was stirred at rt under N2 atmosphere for 2-4 h. The solvent was removed under reduced pressure.

As the paragraph descriping shows that 96929-05-4 is playing an increasingly important role.

Reference：
Article; Pena, Stella; Scarone, Laura; Manta, Eduardo; Serra, Gloria; Tetrahedron Letters; vol. 54; 22; (2013); p. 2806 – 2808;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

15864-32-1, 2-Amino-6-bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 25 mL of 10 M potassium hydroxide solution was added 5 g of 2-amino-6-bromo-benzothiazole,After adding 5 mL of ethylene glycol, the mixture was stirred at 125 C. for 2 h to obtain 2-amino-5-bromobenzenethiol, 15864-32-1

The synthetic route of 15864-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; NEUBORON MEDTECH LTD.; LIU, YUAN HAO; CHEN, JUI FEN; HE, JING; (35 pag.)TW2017/22441; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14779-17-0,2-Amino-5-methylbenzothiazole,as a common compound, the synthetic route is as follows.

3,3-difluoro-2-(phenylethynyl)-3H-indole II-1 (57.0 mg, was added sequentially to a 5 mL reaction flask.0.225 mmol), 5-methylbenzo[d]thiazol-2-amine III-2 (24.6 mg, 0.15 mmol), catalyst TBD (9.8 mg,0.075 mmol) and 1,1,2,2-tetrachloroethane (2.0 mL) were stirred at room temperature for 5 h. The TLC test material has basically been reacted and the reaction is stopped. The reaction solution is directly subjected to column chromatography.Eluent (ethyl acetate / dichloromethane = 1 / 20),Yellow solid product I-9 (47.5 mg) was obtained with a yield of 76%.

14779-17-0, 14779-17-0 2-Amino-5-methylbenzothiazole 26889, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Guangzhou University; Liu Yunlin; Lin Xiaotong; Mao Xiangyu; Chen Guoshu; (15 pag.)CN108586495; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

58249-69-7,58249-69-7, 5,6-Dimethoxybenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

LDA (2.0M in THF, 0.6lmL, l.22mmol) was added dropwise to a mixture of 5,6- dimethoxybenzo[d]thiazole (200mg, l.02mmol) in THF (5.0mL) at -78C under N2. The reaction mixture was stirred at -78C for 1 hour. A mixture of succinic anhydride (l23mg, l.22mmol) in THF (2.0mL) was then added dropwise to the reaction mixture at -78C. The reaction mixture was warmed to RT and stirred for 2 hours. A solution of sat aq NH4Cl (l.OmL) and H20 (5.0mL) were then added to the reaction mixture. The reaction mixture was extracted with EtOAc (3x30mL). The organic layers were combined, washed with brine (20mL), dried over MgS04, filtered, and concentrated under reduced pressure. The residue was purified by reverse phase HPLC (eluting ACN in H20 with 0.1% TFA) to afford 4-(5,6-dimethoxybenzo[d] thiazol-2-yl)-4-oxobutanoic acid. LCMS (CI3HI4N05S) (ES, m/z): 296 [M+H]+. ‘ H NMR (400 MHz, DMSO-ri6) d 7.76 (s, 1H), 7.75 (s, 1H), 3.89 (s, 3H), 3.88 (s, 3H), 3.40-3.34 (m, 2H), 2.67- 2.63 (m, 2H).

The synthetic route of 58249-69-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; MERCK SHARP & DOHME CORP.; ALTMAN, Michael, D.; CASH, Brandon, D.; CUMMING, Jared, N.; DEMONG, Duane, E.; HAIDLE, Andrew, M.; JEWELL, James, P.; LARSEN, Matthew, A.; LU, Min; OTTE, Ryan, D.; TAOKA, Brandon, M.; TROTTER, Benjamin Wesley; TRUONG, Quang, T.; (97 pag.)WO2019/195063; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.81569-46-2,Methyl 2-bromo-5-ethylthiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

81569-46-2, 4-(5-ethyl-4-(methoxycarbonyl)-1,3-thiazol-2-yl)benzoic acid The desired product was prepared by substituting methyl 2-bromo-5-ethylthiazole-4-carboxylate (prepared according to the procedure described in J. Chem. Soc. Perkin I 1982, 159-164) for 6-bromoindole in Example 4A.

81569-46-2 Methyl 2-bromo-5-ethylthiazole-4-carboxylate 13015592, athiazole compound, is more and more widely used in various fields.

Reference：
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/55631; (2002); A1;; ; Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/86887; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3622-35-3, Step A. Benzothiazole-6-carbonyl chloride Under anhydrous conditions, a mixture of benzothiazole-6-carboxylic acid (1.0 g, 5.6 mmol) and oxalyl chloride (0.5 mL, 5.6 mmol) in dichloromethane (25 mL) containing a catalytic amount of N,N-dimethylformamide was stirred at ambient temperature for 3 hours. Removal of the solvent in vacuo provided a quantitative yield of the acid chloride as a light brown solid, which was used as such in the next step.

The synthetic route of 3622-35-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Wyeth; EP1149104; (2002); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

119778-44-8, 4-Ethyl-2-methylthiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,119778-44-8

EXAMPLE 5 (Compound No. 5) To a solution of imidazole (2.72 g; 40 mmol) in dry tetrahydrofuran (60 ml) was added dropwise thionyl chloride (1.20 g; 10 mmol) under ice-cooling while stirring. After the resultant mixture was turned to room temperature, 2-methyl-4-ethyl-5-thiazolecarboxylic acid (1.71 g; 10 mmol) was added thereto at once, and stirring was continued for 30 minutes. To the mixture was added dropwise a solution of 2-(2-furyl)aminoacetonitrile (1.46 g; 12 mmol) in dry tetrahydrofuran under ice-cooling, and the resultant mixture was stirred at room temperature for 1 hour. After completion of the reaction, tetrahydrofuran was removed under reduced pressure to separate the residue. Water was added to the residue, which was extracted with ethyl acetate. The ethyl acetate layer was washed with water twice, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give crude oil. The oil was purified by silica-gel column chromatography (eluent:n-hexane:ethyl acetate=2:1 volume) to give crude crystals. Recrystallization from n-hexane/ethyl acetate gave 1.58 g of 2-(2 -methyl-4-ethylthiazole-5-carboxamido)-2-(2-furyl)acetonitrile as colorless crystals. m.p., 125-126 C. Yield, 57%.

The synthetic route of 119778-44-8 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Sumitomo Chemical Company Limited; US4918089; (1990); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of 1-12 (0.27 g, 0.001 mol) and 2,6-dimethylisonicotinic acid (0.16 g, 0.001 mol) in DCM (10 mL) was treated with DIPEA (0.69 mL, 0.75 g/mL, 0.004 mol) and HBTU (0.38 g, 0.001 mol). Stirring was continued for 16 h. The RM was diluted with water (5 mL), acidified with 1 M HC1 until pH~3 and the layers were separated and the OL was washed with 1 M NaOH until pH~9, water, then dried over MgS04, filtered and concentrated in vacuo to give an oil (0.8 g). A purification was performed via Prep HPLC (stationary phase: RP XBridge Prep C18 OBD-IotaOmicronmuiotaeta, 50 xl50mm, mobile phase: 0.25% NH4HCO3 solution in water, MeOH) yielding two fractions. A purification was performed using Prep SFC (stationary phase: Chiralpak Diacel AD 20 x 250 mm, mobile phase: C02, EtOH with 0.4% iPrNH2) yielding 4 fractions of which two afforded compounds lb (64 mg, 18%) and la (70 mg, 19%)., 3622-35-3

As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Patent; JANSSEN PHARMACEUTICA NV; VAN ROOSBROECK, Yves, Emiel, Maria; VAN DEN KEYBUS, Frans, Alfons, Maria; TRESADERN, Gary, John; BUIJNSTERS, Peter, Jacobus, Johannes, Antonius; VELTER, Adriana, Ingrid; JACOBY, Edgar; MACDONALD, Gregor, James; GIJSEN, Henricus, Jacobus, Maria; AHNAOU, Abdellah; DRINKENBURG, Wilhelmus, Helena, Ignatius, Maria; (216 pag.)WO2018/83098; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a suspension of N-(3-dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride (EDCI) (0.100 g, 0.520 mmol) in THF (4 mL),were added 1-hydroxybenzotriazole (HOBt) (0.059 g, 0.440 mmol)and the corresponding carboxylic acid (b-f) (0.400 mmol). After30 min, a solution of N-methyl-4-(naphthalen-2-ylmethoxy)aniline(9) (0.105 g, 0.400 mmol) and Et3N (0.121 g, 0.167 mL,1.20 mmol) in THF (1 mL) was added and the mixture was stirredover 3 d. The reaction was then diluted with CH2Cl2 (10 mL) andthe resulting solution was concentrated in vacuo onto celite. Theresidue was purified by gradient column chromatography (SiO2,flash, 0-100% EtOAc/heptane) to isolate the title compounds (3b-f) after solvent removal.., 3622-35-3

As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Article; Vlasceanu, Alexandru; Jessing, Mikkel; Kilburn, John Paul; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4453 – 4461;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of Benzothiazole-6-carbonyl chloride (19A, Ar2=benzothiazol-6-yl) Under a nitrogen atmosphere, benzothiazole-6-carboxylic acid (1.014 g, 5.6 mmol) was dissolved in methylene chloride (25 mL). Five drops of N,N-dimethylforamide was added. Oxalyl chloride (0.5 mL, 5.6 mmol) was slowly added. After 2 hrs, the reaction was heated to 30 C. for 16 hrs. The reaction was concentrated in vacuo to yield benzothiazole-6-carbonyl chloride (19A) (1.665 g, quant., light yellow powder).

3622-35-3, As the paragraph descriping shows that 3622-35-3 is playing an increasingly important role.

Reference：
Patent; Nivalis Therapeutics, Inc.; Wasley, Jan; Rosenthal, Gary J.; Sun, Xicheng; Strong, Sarah; Qiu, Jian; US9138427; (2015); B2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica