With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1849-73-6,7-Chlorobenzo[d]thiazole-2(3H)-thione,as a common compound, the synthetic route is as follows.
In a 3-necked round bottomed flask, containing a magnetic stirrer, 80 mg (0.36mmol) of delta-amino^-bromo-i -methyl-I H-imidazole^- carboxamide, 0.16 g (1.83 mmol) of LiBr, 98 mg (0.80 mmol) of potassium te/t-butoxide and 8.85g (64mmol) of 7-chloro-benzothiazole-2-thiol were weighted. The flask was purged with argon and 6ml of distilled DMF were added by syringe. The resulting suspension was stirred overnight at 13O0C. After this, the solvent was removed under high vacuum and the crude was purified through flash chromatography (SiO2, CH2CI2/MeOH : 96/4 affording the 5-amino-2-(7- chloro-benzothiazol-2-ylsulfanyl)-1 -methyl-1 H-imidazole-4-carboxamide compound (38 mg, 31 percent) as a foam. 1H-NMR [CD3OD, delta, ppm]: 7.81 (m, 1 H), 7.48 (m, 1 H), 7.42 (m, 1 H), 3.56 (s, 3H, CH3). MS (El, m/z) 340 (M++1 )., 1849-73-6
As the paragraph descriping shows that 1849-73-6 is playing an increasingly important role.
Reference：
Patent; CRYSTAX PHARMACEUTICALS, S.L.; WO2009/7399; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica