3622-35-3, Benzo[d]thiazole-6-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of 2,7-diazaspiro[4.5]decane-6,8-dione hydrochloride (30 mg, 147 prnol, eq. 1) and benzo[d]thiazole-6-carboxylic acid (CAS 3622-35-3, 28.9 mg, 161 pmol, eq. 1.1) were added a solution of HATU in ACV-dimethylformamide 0.358 M (491 m, 176 mhio, eq. 1.2) and iVyV-diisopropylethyl amine (75.8 mg, 100 m, 586 mpio, eq. 4). The reaction mixture was shaken at 25 C for 4 hours. The reaction mixture was partitioned between water and a 1 : 1 mixture of ethyl acetate and tetrahydrofuran. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The crude material was purified by flash chromatography (silica gel, 4 g, eluent: 0 to 10% of methanol in dichloromethane) to afford 2-(benzo[d]thiazole-6- carbonyl)-2,7-diazaspiro[4.5]decane-6,8-dione (17 mg, 51.6 mhio, 35.2 %) as a white solid. MS (ISP): 330.1 (|M 1 11 )
3622-35-3, 3622-35-3 Benzo[d]thiazole-6-carboxylic acid 601670, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; C4 THERAPEUTICS, INC.; NASVESCHUK, Christopher, G.; DEY, Fabian; GOERGLER, Annick; KUHN, Bernd; NORCROSS, Roger; ROEVER, Stephan; SCHMID, Philipp; (270 pag.)WO2019/204354; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica