With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64987-16-2,Methyl 2-(2-aminothiazol-4-yl)acetate,as a common compound, the synthetic route is as follows.,64987-16-2
Methyl-2-amino-4-thiazolacetate (420 mg, 2.5 mmol) was added to a solution of 2-methylnicotinaldehyde (300 mg, 2.5 mmol) in 1,2-dichloroethane (5 mL), followed by sodium triacetoxyborohydride (1.0 g, 5.0 mmol) at 0. The reaction mixture was allowed to come to rt and stirred for 10 h. The reaction mixture was quenched with 10% aqueous NaHCO3 solution and extracted with EtOAc. The combined extracts were dried over anhydrous sodium sulfate. Solvent was removed under reduced pressure and the crude product was purified by column chromatography (silica gel 60-120 mesh, eluent 5-10% MeOH in CH2Cl2) to afford methyl 2-(2-(((2-methylpyridin-3-yl)methyl)amino)thiazol-4-yl)acetate (80 mg) along with (2-methyl-pyridin-3-yl)-methanol as mixture. TLC: 100% EtOAc, Rf = 0.3. LC-MS purity >40%
As the paragraph descriping shows that 64987-16-2 is playing an increasingly important role.
Reference：
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19621; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica