824403-26-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.824403-26-1,5-Bromo-2-chlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.
To a solution of 5-bromo-2-chlorobenzo[cf]thiazole (0.9 g, 3.62 mmol) in ethanol (12 ml), was added 4 M methyl amine solution (1 ml_) and the reaction mixture was heated at 150 C for 45 min using a Biotage microwave. The reaction mixture was cooled to room temperature. The solvent was removed under reduced pressure, and the crude reaction mixture was purified by flash column chromatography using hexane: ethyl acetate (50:50) to afford the title compound as a solid (0.57 g, 65%).1H-NMR (400 MHz, CDCI3) d = 7.68 (t, J = 2.0 Hz, 1 H), 7.46 (d, J = 8.3 Hz, 1 H), 7.29 (d, J = 0.7 Hz, 1 H), 7.22 (dd, J = 8.4, 1.9 Hz, 1 H), 5.90 (s, 1 H), 3.13 (s, 3H).
824403-26-1 5-Bromo-2-chlorobenzo[d]thiazole 20251269, athiazole compound, is more and more widely used in various fields.
Reference：
Patent; AC IMMUNE SA; NAMPALLY, Sreenivasachary; GABELLIERI, Emanuele; MOLETTE, Jerome; (0 pag.)WO2019/233883; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica