With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127426-30-6,2,5-Dichlorothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.
127426-30-6, EXAMPLE A10 STR47 A stirred mixture of 143.5 g (0.725 mol) of 2,5-dichlorothiazole-4-carboxylic acid and 700 ml of thionyl chloride is slowly heated. Vigorous evolution of gas starts already at about 40 C. The mixture is brought to reflux temperature in the course of half an hour and maintained at this temperature until evolution of gas has ceased (about 2 hours): end temperature about 80 C. After the excess thionyl chloride has been stripped off in a water pump vacuum, 144.6 g (92.2 % of theory) of crystalline 4-chlorocarbonyl-2,5-dichlorothiazole remain, large, colorless crystals of melting point 58-59 C. from petroleum ether. STR48
The synthetic route of 127426-30-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bayer Aktiengesellschaft; US5071865; (1991); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica