With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3622-35-3,Benzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.
(Intermediate Example 114) Methyl 2-amino-3-[(benzothiazole-6-carbonyl)amino]propionate Benzothiazole-6-carboxylic acid (358 mg), N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (382 mg) and hydroxybenzotriazole (306 mg) were dissolved in N,N-dimethylformamide (10 ml) and stirred for 30 minutes with ice cooling. A solution of methyl 3-amino-2-t-butoxycarbonylaminopropionate (560 mg) in N, N-dimethylformamide (8 ml) was added thereto, and the mixture was stirred for 17 hours at a temperature ranging from ice cooling to room temperature. The reaction mixture was concentrated under reduced pressure, and the organic phase was extracted by adding water and ethyl acetate. The organic phase was washed with 10% citric acid solution, 4% sodium bicarbonate solution and water, and dried over sodium sulfate anhydrous. The reaction product was concentrated under reduced pressure to give methyl 3-[(benzothiazole-6-carbonyl)amino]-2-t-butoxycarbonylamino propionate (750 mg, Y.: 98.8%).
3622-35-3, The synthetic route of 3622-35-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; SANWA KAGAKU KENKYUSHO CO., LTD.; EP1595866; (2005); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica